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Journal of Diagnostic Medical Sonography, Vol. 16, No. 1, 14-20 (2000)
DOI: 10.1177/875647930001600103
© 2000 Society of Diagnostic Medical Sonography

An Easily Implemented Method to Improve Detection of Ultrasound Contrast in Body Tissues

Frame-one Imaging

Daniel A. Merton, BS, RDMS

The Jefferson Ultrasound Research and Education Institute, Department of Radiology, Thomas Jefferson University, 132 S. 10th Street, Philadelphia, PA 19107.

The recent commercial availability of ultrasound contrast agents poses new challenges to ultrasound lprofessionals. There is a need to identify the most:relevant clinical applications for which the agents are indicated, as well as ways jin which to use existing ultrasound technology with contrast. Herein is described la new imaging tehnique frame-one maging that: imp rovsthe detection of contrast in bo0d:tissues. Frame-one imaging was attempted in six examin attons of suspected renal abnormalities performed as part of the FDA Phase IcliIcIal trials of the contrast agent Definity® (DuPont Pharmaceuticals, N. Billerica,: M, A). Conventional and harmonic gray-scale imaging was perfrmed at baseline and postcntrat addm inistration. US imaging results were compared to surgical findings. U1, sing gray-scalle harm: o:nicimagg, improved depiction: of:contrast enhancement was achieved in all:cases where FOI was employed. Contrast enhancement was better demonstrated using the FOI tchnique than with continuous real-time imaging. FOI improved the display of contrast enhancement from within normal tissues and vessels as wel as:frombi tumor vessels and tumor tissue. FOI may permit improved tumor characterization using contrasenhanced sonogphy. Additiol vestigations are neede to determine if FOL can imp0rovethe diagnostic potential of contrast-enhanced sonography.

Key Words: ultrasound • sonography • contrast • new technology • renal sonography


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