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Journal of Diagnostic Medical Sonography
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Gyriform Liver Foci in Chronic Hepatic Porphyria

Dinko Berkovic, MD

From the Center of Internal Medicine, Clinic of the Georg-August-University, Göttingen, Germany, berkovic{at}gmx.de

Wilhelm Nolte, MD

From the Center of Internal Medicine, Clinic of the Georg-August-University, Göttingen, Germany

A patient with suspected liver metastases detected by routine sonography of the abdomen was admitted to our clinic for further testing. Liver sonography disclosed multiple irregular gyriform foci of a hyperechoic structure with a maximum diameter of 3.5 cm. In magnetic resonance imaging, these foci appeared as hyperintense in T1-weighted images and isointense in T2-weighted images. A biopsy showed a discrete portal and periportal fibrosis. UV light fluorescence of the specimen was negative. Analysis of urine revealed an almost fourfold el-evation of total porphyrin of 591 µg/24 h, proving the diagnosis of chronic hepatic porphyria. Characteristic liver foci in hepatic porphyria are detected by sonography in some affected patients. Usually, they can also be depicted by magnetic resonance imaging and computed tomography. These foci often appear before any other symptoms of the disease and are reversible when triggering factors, such as certain drugs or alcohol, are discontinued.

Key Words: chronic hepatic porphyria • gyriform liver foci • routine sonography

Journal of Diagnostic Medical Sonography, Vol. 19, No. 5, 308-311 (2003)
DOI: 10.1177/8756479303256087
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