This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Reif, P. A. Search for Related Content Social Bookmarking                         What's this?

Uterine Leiomyosarcoma Mimicking Benign Submucosal Leiomyoma

Obstetrics and Gynecology, Saginaw, Michigan, madfam5{at}airadv.net

Uterine leiomyosarcoma is a rare, aggressive tumor of the smooth muscle with a typical intramural location. Patients present with abnormal uterine bleeding and an enlarged pelvic mass with clinical signs and symptoms that are virtually indistinguishable from benign leiomyoma. Sonographically, leiomyosarcoma presents as a large solitary tumor that closely resembles a benign leiomyoma that may be undergoing degenerative changes. Because of the infiltrative nature of leiomyosarcoma, invasion into the myometrium may be demonstrated. Leiomyosarcoma has a poor prognosis due to local pelvic recurrences and spread to distant sites. This case report demonstrates a fast-growing submucosal leiomyosarcoma with characteristic sonographic echo enhancement and infiltration into the myometrium.

Key Words: abnormal uterine bleeding • myometrium • sonography • uterine leiomyosarcoma

References

• DiSaia PJ, Creasman WT: Clinical Gynecology Oncology. 6th ed. St. Louis, MO, Mosby, 2002.
• Stenchever MA, Droegemueller W., Herbst AL, Mishell DR: Gynecologic Oncology. 4th ed. St. Louis, MO, Mosby, 2001.
• Hoskins WJ, Perez CA, Young RC, Barakat RR, Markman M., Randall ME: Principles and Practice of Gynecologic Oncology. 4th ed. Philadelphia, Lippincott Williams & Wilkins, 2005.
• Smith S., Riethman J., Lomax C.: Sonography of uterine leiomyosarcoma. J Diagn Med Sonography 2002;18:35—37.
• Berman MC, Cohen HL (eds): Obstetrics and Gynecology. 2nd ed. Philadelphia, Lippincott-Raven, 1997.
• Sabbagha RE (ed): Diagnostic Ultrasound Applied to Obstetrics and Gynecology. 3rd ed. Philadelphia, Lippincott, 1994.
• Vitiello D., McCarthy S.: Diagnostic imaging of myomas. Obstet Gynecol Clin N Am 2006;33:85—95.[CrossRef][Medline] [Order article via Infotrieve]
• DeVita VT, Hellman S, Rosenberg SA (eds): Cancer Principles & Practice of Oncology. 7th ed. Philadelphia, Lippincott Williams & Wilkins, 2005.
• Peng YJ, Hueng GG, Lee HS: Acute heart failure as manifestation of metastatic uterine leiomyosarcoma to the heart and lung. Heart Lung 2004;33:46—49.[CrossRef][Medline] [Order article via Infotrieve]
• Abeloff MD, Armitage JO, Niederhuber JE, Kastan MB, McKenna WG: Clinical Oncology. 3rd ed. Philadelphia, Elsevier, 2004.
• Berek JS, Hacker NF: Practical Gynecologic Oncology. 4th ed. Philadelphia, Lippincott Williams & Wilkins, 2005.
• Clement PB: The pathology of uterine smooth muscle tumors and mixed endometrial stromal-smooth muscle tumors: a selective review with emphasis on recent advances. Int J Gynecol Pathol 2000;19:39—55.[Medline] [Order article via Infotrieve]
• Kurman R (ed): Blaustein's Pathology of the Female Genital Tract. 5th ed. New York, Springer-Verlag, 2001.
• Lefebvre G., Vilos G., Allaire C., Jeffrey J. The management of uterine leiomyomas. J Obstet Gynaecol Can 2003;25: 396—405.[Medline] [Order article via Infotrieve]
• Aviram R., Ochshorn Y., Markovitch O., et al. Uterine sarcomas versus leiomyomas: gray-scale and Doppler sonographic findings. J Clin Ultrasound 2004;33:10—13.[CrossRef]
• Connors AM, DeSouza NM, NcIndoe GA: Adenomyoma mimicking an aggressive uterine neoplasm on MRI. Br J Radiol 2003;76:66—68.[Abstract/Free Full Text]
• Schwartz PE, Kelly MG: Malignant transformation of myomas: myth or reality? Obstet Gynecol Clin N Am 2006;33:183—198.[CrossRef][Medline] [Order article via Infotrieve]
• Giuntoli RL, Bristow RE: Uterine leiomyosarcoma: present management. Curr Opin Oncol 2000;16:324—327.[CrossRef]

Journal of Diagnostic Medical Sonography, Vol. 23, No. 6, 368-371 (2007)
DOI: 10.1177/8756479307309414


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Reif, P. A. Search for Related Content Social Bookmarking                         What's this?